I thought that I read about this on this board, but I searched and couldn't find it. My question is this: Is it OK to set the guides a little to the left of center? In other words, with the guides facing up and sighting along the rod, the guides are a smidgen to the left of the center line. I would think that this might help the right hand caster because when casting a fly rod, the wrist always twists a bit. With the guides a little off, it would keep the line load more opposite the rod. Am I crazy to think this? I'm not talking way off center, more like 5 degrees or less. Thoughts?

I think it would be a waste of time. The line is moving in a pretty big ring and I just don't think you could ever tell the difference. Others may disagree.

I don't see how you could even do that. If you put all the guides off the centerline by the same amount, you've created a new centerline. Right?

Jamie,
I assume that you mean that you have wrapped the rod and the guides are about 5 degrees off of center relative to the reel on your fly rod. Maybe someone else will disagree but I do not see how this is really going to have any serious draw back or cause any serious harm. As far as alligning the guides that way intentionally is concerned, I guess that I do not see the point. Instead you can always hold the rod in such a way that the guides are off center a little relative to the plane of your cast to compensate for any twist in your wrist.

Jamie,
I think your time may be better spent practice casting until your wrist twist goes away. I used to have loose wrists as well, but someone told me to try casting with my index finger on top. That showed me what the correct casting plane should look and feel like, but it's not a permanent solution as you can't get as much power as you can with thumb on top. You might want to give it a try.